Belyntic's Peptide Easy Clean (PEC) technology breaks barriers in peptide manufacturing. We designed a catch-and-release methodology based on novel traceless cleavable linker molecules (PEC-Linkers) and activated filter materials for the purification and modification of chemically synthesized peptides.

Apr 18, 2012 Site-specific chemical modification of antibody fragments Site-specific chemical modification of antibody fragments using traceless cleavable linkers. Gonçalo J L Bernardes 1,2,3, Martina Steiner 1, Isabelle Hartmann 1, Dario Neri 1 & Delivery and Release of Small-Molecule Probes in Here, we describe cleavable linkers designed for the traceless release of chemical cargo from MPPs following mitochondrial transit. The cleavage kinetics of a number of disulfides were investigated using a fluorescent reporter system in order to optimize linker stability for mitochondrial release. The stability of mono- and disubstituted Cleavable vs. Non-Cleavable Linkers in Antibody-Drug Dec 19, 2019

However, upon cleavage, residual atoms from the linker remain attached to the protein, potentially complicating downstream processes such as activity assays or proteomic analysis. Thus, traceless cleavage 13, 17, 18 in which the unmodified parent protein is released is a key requirement for new biotinylation reagents.

Traceless | Definition of Traceless at Dictionary.com

Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase

Jul 13, 2019 · Cleavable linkers used in antibody-drug conjugates toady may include a variety of linker chemistries, such as hydrazone and hydrazide moieties, disulfide containing linkers such as N-succinimidyl-4- (2-pyridyldithio)pentanoate (SPP) and N-succinimidyl-4- (2-pyridyldithio)butyrate (SPDB), 4- (4’-acetylphenoxy)butanoic acid (AcBut) linkers, dipeptides valine-citrulline (Val-Cit) and phenylalanine-lysine (Phe-Lys) type linkers.